Lisinopril Dihydrate

  • CAT Number: A001043
  • CAS Number: 83915-83-7
  • Molecular Formula: C21H35N3O7
  • Molecular Weight: 441.525
  • Purity: ≥95%
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Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class used primarily in treatment of high blood pressure, heart failure, and after heart attacks. It is also used for preventing kidney and eye complications in people with diabetes. Its indications, contraindications, and side effects are as those for all ACE inhibitors.

Catalog Number A001043
CAS Number 83915-83-7
Molecular Formula

C21H35N3O7

Purity 95%
Target ACE Inhibitor
Storage -20°C
InChI 1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1
InChIKey CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
SMILES C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
Reference

1: Sorrenti M, Catenacci L, Cruickshank DL, Caira MR. Lisinopril dihydrate:
single-crystal x-ray structure and physicochemical characterization of derived
solid forms. J Pharm Sci. 2013 Oct;102(10):3596-603. doi: 10.1002/jps.23660. Epub
2013 Jul 19. PubMed PMID: 23873413.
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2: Wang SL, Lin SY, Chen TF. Thermal-Dependent dehydration process and
intramolecular cyclization of lisinopril dihydrate in the solid state. Chem Pharm
Bull (Tokyo). 2000 Dec;48(12):1890-3. PubMed PMID: 11145138.
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3: Ozdemir HS, Aksulu HE, Karata&#351; F, Ustündag B, Bing&#246;l I. Long-term lisinopril
dihydrate application decreases plasma noradrenaline but not adrenaline levels in
chickens. Physiol Res. 2000;49(1):183-8. PubMed PMID: 10805421.
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4: Derayea SM, Badr El-Din KM, Mohammed FF. An innovative validated
spectrofluorimetric method for determination of Lisinopril in presence of
hydrochlorothiazide; application to content uniformity testing. Spectrochim Acta
A Mol Biomol Spectrosc. 2018 Jan 5;188:318-323. doi: 10.1016/j.saa.2017.07.021.
Epub 2017 Jul 17. PubMed PMID: 28750308.

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5: Olamoyegun M, Kolawole B, Ajayi AAL. Influence of West African Ethnicity and
Gender on Beta-Cell Function and Insulin Sensitivity in Essential Hypertensives
Treated with Hydrochlorothiazide and Hydrochlorothiazide-lisinopril Combination.
J Pharmacol Pharmacother. 2017 Apr-Jun;8(2):68-73. doi: 10.4103/jpp.JPP_140_16.
PubMed PMID: 28706401; PubMed Central PMCID: PMC5497402.
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6: Derayea SM, Badr El-Din KM, Mohammed FF. Selective spectrofluorimetric method
for determination of Lisinopril in pharmaceutical preparations and in presence of
hydrochlorothiazide: Application to content uniformity testing. Luminescence.
2017 Dec;32(8):1482-1487. doi: 10.1002/bio.3348. Epub 2017 Jul 6. PubMed PMID:
28681525.
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7: Fahelelbom KMS, Al-Tabakha MMM, Eissa NAM, Javadi J. Evaluation of Certain
Pharmaceutical Quality Attributes of Lisinopril Split Tablets. Sci Pharm. 2016
Oct 11;84(4):646-653. doi: 10.3390/scipharm84040646. PubMed PMID: 28656943.

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8: Guglin M, Munster P, Fink A, Krischer J. Lisinopril or Coreg CR in reducing
cardiotoxicity in women with breast cancer receiving trastuzumab: A rationale and
design of a randomized clinical trial. Am Heart J. 2017 Jun;188:87-92. doi:
10.1016/j.ahj.2017.03.010. Epub 2017 Mar 22. PubMed PMID: 28577685; PubMed
Central PMCID: PMC5458618.
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9: Abbasi Pour S, Shaterian HR. Design and characterization of lisinopril-loaded
superparamagnetic nanoparticles as a new contrast agent for in vitro, in vivo MRI
imaging, diagnose the tumors and drug delivery system. J Mater Sci Mater Med.
2017 Jun;28(6):91. doi: 10.1007/s10856-017-5900-0. Epub 2017 May 11. PubMed PMID:
28497361.

<br>
10: Fr&#246;hlich H, Henning F, T&#228;ger T, Schellberg D, Grundtvig M, Goode K, Corletto
A, Kazmi S, Hole T, Katus HA, Atar D, Cleland JGF, Agewall S, Frankenstein L,
Clark AL. Comparative effectiveness of enalapril, lisinopril and ramipril in the
treatment of patients with chronic heart failure. A propensity score matched
cohort study. Eur Heart J Cardiovasc Pharmacother. 2017 May 5. doi:
10.1093/ehjcvp/pvx013. [Epub ahead of print] PubMed PMID: 28475676.

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