For research use only. Not for therapeutic Use.
Lirimilast(CAT: I017462) is an orally active phosphodiesterase-4 (PDE4) inhibitor developed for the treatment of inflammatory and respiratory disorders. By selectively inhibiting PDE4, Lirimilast elevates intracellular cAMP levels, leading to the suppression of pro-inflammatory cytokines such as TNF-α and IL-6. This mechanism supports its application in conditions like chronic obstructive pulmonary disease (COPD), asthma, and other immune-mediated diseases. Preclinical and clinical research has demonstrated its ability to reduce airway inflammation and modulate immune responses without significant broad immunosuppression. Lirimilast serves as a valuable research tool for exploring inflammation, immunology, and respiratory disease pharmacology.
| CAS Number | 329306-27-6 |
| Synonyms | [3-(carbamoylamino)-2-(2,4-dichlorobenzoyl)-1-benzofuran-6-yl] methanesulfonate |
| Molecular Formula | C17H12Cl2N2O6S |
| Purity | ≥95% |
| IUPAC Name | [3-(carbamoylamino)-2-(2,4-dichlorobenzoyl)-1-benzofuran-6-yl] methanesulfonate |
| InChI | InChI=1S/C17H12Cl2N2O6S/c1-28(24,25)27-9-3-5-11-13(7-9)26-16(14(11)21-17(20)23)15(22)10-4-2-8(18)6-12(10)19/h2-7H,1H3,(H3,20,21,23) |
| InChIKey | YPFLFUJKZDAXRA-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)OC1=CC2=C(C=C1)C(=C(O2)C(=O)C3=C(C=C(C=C3)Cl)Cl)NC(=O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
