Linopirdine dihydrochloride

• CAT Number: I010490
• CAS Number: 113168-57-3
• Molecular Formula: C26H23Cl2N3O
• Molecular Weight: 464.39
• Purity: ≥95%
• Target: Potassium Channel
• Solubility: Soluble to 100 mM in water and to 100 mM in DMSO
• Storage: Desiccate at RT
• IUPAC Name: 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one;dihydrochloride
• InChI: InChI=1S/C26H21N3O.2ClH/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22;;/h1-17H,18-19H2;2*1H
• InChIKey: ZEVVHCGTTNRYOY-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)N2C3=CC=CC=C3C(C2=O)(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl

Linopirdine dihydrochloride (CAT: I010490) is a chemical compound that functions as a blocker of KV7 (KCNQ) voltage-gated potassium channels. It is known to selectively block KV7.1 + 7.3 (KCNQ2 + 3) / M-currents with an IC50 ranging from 4 to 7 μM. Additionally, it has an inhibitory effect on KV7.1 (KCNQ1) homomeric channels with an IC50 of approximately 8.9 μM. The ability of linopirdine dihydrochloride to modulate these specific potassium channels makes it a valuable tool for studying neuronal excitability, ion channel function, and potential therapeutic applications related to these channels.