LIN28 inhibitor LI71 enantiomer

• CAT Number: R039371
• CAS Number: 956189-58-5
• Molecular Formula: C21H21NO3
• Molecular Weight: 335.40
• Purity: ≥95%
• Synonyms: 4-[(3aR,4S,9bS)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid
• InChI: InChI=1S/C21H21NO3/c1-2-25-18-8-4-7-17-15-5-3-6-16(15)19(22-20(17)18)13-9-11-14(12-10-13)21(23)24/h3-5,7-12,15-16,19,22H,2,6H2,1H3,(H,23,24)/t15-,16+,19+/m0/s1
• InChIKey: QWJMABCFVYELBB-FRQCXROJSA-N
• SMILES: CCOC1=CC=CC2=C1NC(C3C2C=CC3)C4=CC=C(C=C4)C(=O)O

LIN28 inhibitor LI71 enantiomer (Cat No.: R039371) is a stereoisomer of LI71, a small-molecule inhibitor that selectively targets the RNA-binding protein LIN28, a key regulator of microRNA biogenesis, particularly the let-7 family. By blocking LIN28’s interaction with pre-let-7, this compound restores let-7 maturation, leading to suppression of oncogenes involved in proliferation and stemness. The enantiomeric form provides stereochemical specificity, influencing binding affinity and biological activity. It is used in cancer and stem cell research to study LIN28-mediated pathways and explore therapeutic approaches targeting RNA–protein interactions.

Reference

[1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018;23(10):3091-3101.
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