Bendazol

• CAT Number: I013038
• CAS Number: 621-72-7
• Molecular Formula: C₁₄H₁₂N₂
• Molecular Weight: 208.26
• Purity: ≥95%
• Target: NO Synthase
• Solubility: 10 mM in DMSO
• IUPAC Name: 2-benzyl-1H-benzimidazole
• InChI: InChI=1S/C14H12N2/c1-2-6-11(7-3-1)10-14-15-12-8-4-5-9-13(12)16-14/h1-9H,10H2,(H,15,16)
• InChIKey: YTLQFZVCLXFFRK-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CC2=NC3=CC=CC=C3N2

Bendazol (CAT: I013038) serves as a hypotensive drug with a distinctive mechanism of action. In addition to its hypotensive effects, Bendazol also demonstrates the ability to enhance nitric oxide synthase (NOS) activity specifically in renal glomeruli and collecting tubules. Nitric oxide (NO) plays a vital role in regulating vascular tone and blood pressure. By augmenting NOS activity, Bendazol contributes to increased NO production, which in turn influences vasodilation and helps to regulate blood pressure.

Reference

[1]. Eliseeva EV, et al. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension. Bull Exp Biol Med. 2017 Jan;162(3):357-361.