Limonin

  • CAT Number: I000639
  • CAS Number: 1180-71-8
  • Molecular Formula: C26H30O8
  • Molecular Weight: 470.5
  • Purity: ≥95%
Inquiry Now

<p style=/line-height:25px/>Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.<br>IC50 Value:<br>Target: HIV; anticancer<br>Limonin is a triterpenoid aglycone that is a bitter principle of citrus fruits. Limonin is chemically induced carcinogenesis inhibitor and HIV-1 replication inhibitor. Limonin has anti-proliferative, proapoptotic activity on several cancer cell lines and inhibits azoxymethane-induced colon cancer in rats. Limonin also inhibits HIV-1 replication in culturedf monocytes, macrophages, and mononuclear cells, perhaps by inhibition of HIV-1 protease activity.</p>

Catalog Number I000639
CAS Number 1180-71-8
Molecular Formula

C26H30O8

Purity 95%
Target HIV
Solubility DMSO: ≥ 45 mg/mL
Storage 3 years -20C powder
InChIKey KBDSLGBFQAGHBE-MSGMIQHVSA-N
Reference

</br>1:Dose-response relationship in Schistosoma mansoni juvenile and adult stages following limonin treatment in experimentally infected mice. Eraky MA, El-Kholy AA, Rashed GA, Hammam OA, Moharam AF, Abou-Ouf EA, Aly NS, Kishik SM, Abdallah KF, Hamdan DI.Parasitol Res. 2016 Oct;115(10):4045-54. doi: 10.1007/s00436-016-5177-0. Epub 2016 Jun 20. PMID: 27325399 </br>2:Temporal and spatial variations on accumulation of nomilin and limonin in the pummelos. Wang F, Yu X, Liu X, Shen W, Zhu S, Zhao X.Plant Physiol Biochem. 2016 Sep;106:23-9. doi: 10.1016/j.plaphy.2016.04.039. Epub 2016 Apr 23. PMID: 27135815 </br>3:Dietary supplementation with purified citrus limonin glucoside does not alter ex vivo functions of circulating T lymphocytes or monocytes in overweight/obese human adults. Zunino SJ, Storms DH, Freytag TL, Adkins YC, Bonnel EL, Woodhouse LR, Breksa AP 3rd, Manners GD, Mackey BE, Kelley DS.Nutr Res. 2016 Jan;36(1):24-30. doi: 10.1016/j.nutres.2015.10.011. Epub 2015 Oct 31. PMID: 26773778 </br>4:Limonin, a Component of Dictamni Radicis Cortex, Inhibits Eugenol-Induced Calcium and cAMP Levels and PKA/CREB Signaling Pathway in Non-Neuronal 3T3-L1 Cells. Yoon YC, Kim SH, Kim MJ, Yang HJ, Rhyu MR, Park JH.Molecules. 2015 Dec 10;20(12):22128-36. doi: 10.3390/molecules201219840. PMID: 26690397 Free Article</br>5:Metabolomics strategy reveals therapeutical assessment of limonin on nonbacterial prostatitis. Zhang A, Wang H, Sun H, Zhang Y, An N, Yan G, Meng X, Wang X.Food Funct. 2015 Nov;6(11):3540-9. doi: 10.1039/c5fo00489f. Epub 2015 Aug 24. PMID: 26302114 </br>6:Suppression of intestinal carcinogenesis in Apc-mutant mice by limonin. Shimizu S, Miyamoto S, Fujii G, Nakanishi R, Onuma W, Ozaki Y, Fujimoto K, Yano T, Mutoh M.J Clin Biochem Nutr. 2015 Jul;57(1):39-43. doi: 10.3164/jcbn.15-28. Epub 2015 Jun 17. PMID: 26236099 Free PMC Article</br>7:Total Synthesis of Limonin. Yamashita S, Naruko A, Nakazawa Y, Zhao L, Hayashi Y, Hirama M.Angew Chem Int Ed Engl. 2015 Jul 13;54(29):8538-41. doi: 10.1002/anie.201503794. Epub 2015 Jun 3. PMID: 26036432 </br>8:Species-related difference between limonin and obacunone among five liver microsomes and zebrafish using ultra-high-performance liquid chromatography coupled with a LTQ-Orbitrap mass spectrometer. Ren W, Li Y, Zuo R, Wang HJ, Si N, Zhao HY, Han LY, Yang J, Bian BL.Rapid Commun Mass Spectrom. 2014 Nov 15;28(21):2292-300. doi: 10.1002/rcm.7026. PMID: 25279742 </br>9:Growth inhibition of various human cancer cell lines by imperatorin and limonin from poncirus trifoliata rafin. Seeds. Rahman A, Siddiqui SA, Jakhar R, Kang SC.Anticancer Agents Med Chem. 2015;15(2):236-41. PMID: 25244913 </br>10:Simultaneous purification of limonin, nomilin and isoobacunoic acid from pomelo fruit (Citrus grandis) segment membrane. Xiang Y, Cao J, Luo F, Wang D, Chen W, Li X, Sun C, Chen K.J Food Sci. 2014 Oct;79(10):C1956-63. doi: 10.1111/1750-3841.12581. Epub 2014 Sep 11. PMID: 25212475

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!