LHVS

• CAT Number: I018013
• CAS Number: 170111-28-1
• Molecular Formula: C₂₈H₃₇N₃O₅S
• Molecular Weight: 527.68
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-[(2S)-1-[[(E,3S)-1-(benzenesulfonyl)-5-phenylpent-1-en-3-yl]amino]-4-methyl-1-oxopentan-2-yl]morpholine-4-carboxamide
• InChI: InChI=1S/C28H37N3O5S/c1-22(2)21-26(30-28(33)31-16-18-36-19-17-31)27(32)29-24(14-13-23-9-5-3-6-10-23)15-20-37(34,35)25-11-7-4-8-12-25/h3-12,15,20,22,24,26H,13-14,16-19,21H2,1-2H3,(H,29,32)(H,30,33)/b20-15+/t24-,26-/m0/s1
• InChIKey: YUMYYTORLYHUFW-MSKIIMLESA-N
• SMILES: CC(C)CC(C(=O)NC(CCC1=CC=CC=C1)C=CS(=O)(=O)C2=CC=CC=C2)NC(=O)N3CCOCC3

LHVS（Cat No.:I018013） is a powerful cysteine protease inhibitor known for its non-selective activity. It effectively blocks microprotein secretion, sliding motility, and cell invasion of Toxoplasma gondii, a parasitic protozoan. With an inhibitory concentration (IC50) of 10 μM, LHVS demonstrates potent suppression of these essential processes utilized by T. gondii for survival and invasion.

Reference

[1]. Wilson SR, et al. Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. J Biol Chem. 2009 Jan 23;284(4):2584-92.[2]. Teo CF, et al.Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion. Antimicrob Agents Chemother. 2007 Feb;51(2):679-88.