Levocarnitine

  • CAT Number: A000581
  • CAS Number: 541-15-1
  • Molecular Formula: C7H15NO3
  • Molecular Weight: 161.2
  • Purity: ≥95%
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Levocarnitine, also known as Carnitor and ST-198, is a carnitine acetyltransferase stimulant used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.

Catalog Number A000581
CAS Number 541-15-1
Molecular Formula

C7H15NO3

Purity 95%
Storage -20°C
InChI 1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
InChIKey PHIQHXFUZVPYII-ZCFIWIBFSA-N
SMILES C[N+](C)(C)CC(CC(=O)[O-])O
Reference

1: Ibarra-Sifuentes HR, Del Cueto-Aguilera á, Gallegos-Arguijo DA,
Castillo-Torres SA, Vera-Pineda R, Martínez-Granados RJ, Atilano-Díaz A,
Cuellar-Monterrubio JE, Pezina-Cantú CO, Martínez-Guevara EJ, Ortiz-Treviño JF,
Delgado-García GR, Martínez-Jiménez JG, Cruz-Valdez J, Sánchez-Martínez C.
Levocarnitine Decreases Intradialytic Hypotension Episodes: A Randomized
Controlled Trial. Ther Apher Dial. 2017 Oct;21(5):459-464. doi:
10.1111/1744-9987.12553. Epub 2017 Aug 14. PubMed PMID: 28805348.
<br>

2: Maruyama T, Higuchi T, Yamazaki T, Okawa E, Ando H, Oikawa O, Inoshita A,
Okada K, Abe M. Levocarnitine Injections Decrease the Need for
Erythropoiesis-Stimulating Agents in Hemodialysis Patients with Renal Anemia.
Cardiorenal Med. 2017 Jun;7(3):188-197. doi: 10.1159/000462983. Epub 2017 Apr 20.
PubMed PMID: 28736559; PubMed Central PMCID: PMC5511994.
<br>

3: Blackman A, Boutin A, Shimanovsky A, Baker WJ, Forcello N. Levocarnitine and
vitamin B complex for the treatment of pegaspargase-induced hepatotoxicity: A
case report and review of the literature. J Oncol Pharm Pract. 2017 Jan
1:1078155217710714. doi: 10.1177/1078155217710714. [Epub ahead of print] PubMed
PMID: 28523950.
<br>

4: Yamada M, Kuroda H, Shimoyama S, Ito R, Sugama Y, Sato K, Yamauchi N,
Horiguchi H, Nakamura H, Hamaguchi K, Abe T, Fujii S, Maeda M, Kato J. [Efficacy
of levocarnitine for tyrosine kinase inhibitor-induced painful muscle cramps in
patients with chronic myelogenous leukemia]. Rinsho Ketsueki. 2016
Apr;57(4):489-91. doi: 10.11406/rinketsu.57.489. Japanese. PubMed PMID: 27169456.
<br>

5: Wang SX, Tan L, Wang J, Zhong JQ. Effect of levocarnitine on TIMP-1, ICAM-1
expression of rats with coronary heart disease and its myocardial protection
effect. Asian Pac J Trop Med. 2016 Mar;9(3):269-73. doi:
10.1016/j.apjtm.2016.01.025. Epub 2016 Jan 11. PubMed PMID: 26972400.
<br>

6: Zeiler FA, Sader N, Gillman LM, West M. Levocarnitine induced seizures in
patients on valproic acid: A negative systematic review. Seizure. 2016
Mar;36:36-9. doi: 10.1016/j.seizure.2016.01.020. Epub 2016 Feb 16. Review. PubMed
PMID: 26889779.
<br>

7: Iwasa M, Sugimoto R, Ishihara T, Sekoguchi-Fujikawa N, Yoshikawa K,
Mifuji-Moroka R, Tanaka H, Kobayashi Y, Hasegawa H, Takei Y. Usefulness of
Levocarnitine and/or Branched-Chain Amino Acids during Invasive Treatment for
Hepatocellular Carcinoma. J Nutr Sci Vitaminol (Tokyo). 2015;61(6):433-40. doi:
10.3177/jnsv.61.433. PubMed PMID: 26875483.
<br>

8: Higuchi T, Abe M, Yamazaki T, Okawa E, Ando H, Hotta S, Oikawa O, Kikuchi F,
Okada K, Soma M. Levocarnitine Improves Cardiac Function in Hemodialysis Patients
With Left Ventricular Hypertrophy: A Randomized Controlled Trial. Am J Kidney
Dis. 2016 Feb;67(2):260-70. doi: 10.1053/j.ajkd.2015.09.010. Epub 2015 Oct 23.
PubMed PMID: 26508680.
<br>

9: Novikov DV, Belousov SS, Karaulov AV, Eroshevskaya NV, Shumilova SV, Kasatova
ES, Kazatskaya ZhA, Novikov VV. Levocarnitine normalizes elevated blood level of
soluble Fas mRNA in patients with acute myocardial infarction. Bull Exp Biol Med.
2015 Mar;158(5):617-20. doi: 10.1007/s10517-015-2820-1. Epub 2015 Mar 17. PubMed
PMID: 25778646.
<br>

10: Higuchi T, Abe M, Yamazaki T, Mizuno M, Okawa E, Ando H, Oikawa O, Okada K,
Kikuchi F, Soma M. Effects of levocarnitine on brachial-ankle pulse wave velocity
in hemodialysis patients: a randomized controlled trial. Nutrients. 2014 Dec
22;6(12):5992-6004. doi: 10.3390/nu6125992. PubMed PMID: 25533009; PubMed Central
PMCID: PMC4277011.

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