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Leukadherin-1

Leukadherin-1

  • CAT Number: I003258
  • CAS Number: 344897-95-6
  • Molecular Formula: C22H15NO4S2
  • Molecular Weight: 421.49
  • Purity: ≥95%
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Leukadherin-1(CAT: I003258) is a specific agonist of the leukocyte surface integrin CD11b/CD18, also known as complement receptor 3 (CR3). It specifically activates and enhances the function of CD11b/CD18, leading to increased leukocyte adhesion and migration. This molecule has potential applications in the modulation of immune responses and inflammatory processes. By selectively targeting CD11b/CD18, Leukadherin-1 offers a unique approach to regulating leukocyte functions and has been studied for its therapeutic potential in various inflammatory disorders.

Catalog Number I003258
CAS Number 344897-95-6
Molecular Formula

C22H15NO4S2

Purity 95%
Target Integrin
Solubility DMSO: ≥ 6 mg/mL (Need ultrasonic)
Storage Store at +4C
Reference

</br>1:The complement receptor 3 (CD11b/CD18) agonist Leukadherin-1 suppresses human innate inflammatory signalling. Roberts AL, Fürnrohr BG, Vyse TJ, Rhodes B.Clin Exp Immunol. 2016 Sep;185(3):361-71. doi: 10.1111/cei.12803. Epub 2016 Jul 26. PMID: 27118513 Free PMC Article</br>2:Efficacy of Leukadherin-1 in the Prevention of Hyperoxia-Induced Lung Injury in Neonatal Rats. Jagarapu J, Kelchtermans J, Rong M, Chen S, Hehre D, Hummler S, Faridi MH, Gupta V, Wu S.Am J Respir Cell Mol Biol. 2015 Dec;53(6):793-801. doi: 10.1165/rcmb.2014-0422OC. PMID: 25909334 Free PMC Article</br>3:Agonist leukadherin-1 increases CD11b/CD18-dependent adhesion via membrane tethers. Celik E, Faridi MH, Kumar V, Deep S, Moy VT, Gupta V.Biophys J. 2013 Dec 3;105(11):2517-27. doi: 10.1016/j.bpj.2013.10.020. PMID: 24314082 Free PMC Article

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