Leucinostatin A

• CAT Number: R002707
• CAS Number: 76600-38-9
• Molecular Formula: C62H111N11O13
• Molecular Weight: 1218.6
• Purity: ≥95%
• Storage: -20°C

Leucinostatin A is the major component of an atypical nonapeptide complex produced by Paecilomyces lilacinus, first reported in 1973. Leucinostatins display broad bioactivity against Gram positive bacteria, fungi, plants and tumor cell lines. Leucinostatin A is potentiated by inhibitors such as venturicidin and oligomycin. More recently, interest in leucinostatin has focused on understanding its activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti-trypanosomal activity.Leucinostatin A inhibits respiration by uncoupling oxidative phosphorylation.

Reference

A new antibiotic, leucinostatin, derived from Penicillium lilacinum. Arai T. et al. J. Antibiot. 1973, 26, 157. Isolation of leucinostatin A and one of its constituents, the new amino acid, 4-methyl-6-(2-oxobutyl)-2-piperidinecarboxylic acid, from Paecilomyces lilacinus A-267. Mori Y. et al. J. Antibiot. 1982, 35, 543.Dual inhibitory effects of the peptide antibiotics leucinostatins on oxidative phosphorylation in mitochondria. Shima A. et al. Cell Struct. Funct. 1990, 15, 53.Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Kawada M. et al. Int. J. Cancer 2010, 126, 810.