Leptomycin A

• CAT Number: R005985
• CAS Number: 87081-36-5
• Molecular Formula: C32H46O6
• Molecular Weight: 526.7
• Purity: ≥95%
• Storage: -20°C
• InChIKey: QECBVZBMGUAZDL-WRDLAOIUSA-N

Leptomycin A (Cat.No:R005985) is a natural compound isolated from Streptomyces bacteria. It functions as a potent inhibitor of nuclear export by binding to exportin 1, a cellular protein involved in nucleocytoplasmic transport. Leptomycin A has been widely used in research to study cellular processes, particularly related to nuclear-cytoplasmic trafficking and cancer.

Reference

Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization. Hamamoto T. et al. J Antibiot. 1983, 36, 639.Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation. Hamamoto T. et al. J Antibiot. 1983, 36, 646. Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. Jang B.C. et al. J. Biol. Chem. 2003, 278, 2773.