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Lenalidomide hemihydrate

Lenalidomide hemihydrate

  • CAT Number: I005076
  • CAS Number: 847871-99-2
  • Molecular Formula: C26H28N6O7
  • Molecular Weight: 536.54
  • Purity: ≥95%
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Lenalidomide hemihydrate (Cat.No:I005076) is a pharmaceutical compound that belongs to the class of immunomodulatory drugs. It is used in the treatment of multiple myeloma, myelodysplastic syndromes, and certain types of lymphoma. Lenalidomide hemihydrate works by modulating the immune system and inhibiting the growth of cancer cells. It is typically administered orally and requires medical supervision.

Catalog Number I005076
CAS Number 847871-99-2
Molecular Formula

C26H28N6O7

Purity 95%
Target TNF-α
Solubility 10 mM in DMSO
Storage Store at -20C
IC50 13 nM [1]
Reference

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<br>[1]. Muller GW, et al. Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1625-30.
<br>[2]. Zangari M, et al. Immunomodulatory drugs in multiple myeloma. Expert Opin Investig Drugs. 2005 Nov;14(11):1411-8.
<br>[3]. Lopez-Girona A, et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia. 2012 Nov;26(11):2326-35.
<br>[4]. Rozewski DM, et al. Pharmacokinetics and tissue disposition of lenalidomide in mice. AAPS J. 2012 Dec;14(4):872-82.
<br>[5]. Danbara M, et al. Lenalidomide-induced acute lung injury in case of multiple myeloma. Int J Clin Pharmacol Ther. 2013 Jun;51(6):513-6.
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