Lenalidomide-d5

• CAT Number: R067122
• CAS Number: 1227162-34-6
• Molecular Formula: C13H8D5N3O3
• Molecular Weight: 264.3
• Purity: ≥95%
• Synonyms: 5-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione-3,3,4,4,5-d5
• Storage: 2°C to 8°C
• InChI: InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)/i4D2,5D2,10D
• InChIKey: GOTYRUGSSMKFNF-QTQWIGFBSA-N
• SMILES: NC1=C(CN(C2([2H])C(NC(C([2H])([2H])C2([2H])[2H])=O)=O)C3=O)C3=CC=C1

Lenalidomide-d5 is intended for use as an internal standard for the quantification of lenalidomide (Item No. 14643) by GC- or LC-MS. Lenalidomide is related to thalidomide (Item No. 14610) and, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines. It also induces proliferation and enhances the functional capacity of T lymphocytes, amplifying co-stimulatory signaling pathways. Lenalidomide is effective in hematologic cancers, including lymphomas and myelomas.

Reference

1.Kim, K.,An, S.,Cha, H.J., et al. Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells. Oncol.Lett. 5(2), 588-596 (2013).