LEI-401

• CAT Number: I015142
• CAS Number: 2393840-15-6
• Molecular Formula: C24H31N5O2
• Molecular Weight: 421.54
• Purity: ≥95%
• Synonyms: N-(cyclopropylmethyl)-6-[(3S)-3-hydroxypyrrolidin-1-yl]-2-[(3S)-3-phenylpiperidin-1-yl]pyrimidine-4-carboxamide
• InChI: InChI=1S/C24H31N5O2/c30-20-10-12-28(16-20)22-13-21(23(31)25-14-17-8-9-17)26-24(27-22)29-11-4-7-19(15-29)18-5-2-1-3-6-18/h1-3,5-6,13,17,19-20,30H,4,7-12,14-16H2,(H,25,31)/t19-,20+/m1/s1
• InChIKey: GFHJYPQZBBHOCC-UXHICEINSA-N
• SMILES: C1C[C@H](CN(C1)C2=NC(=CC(=N2)N3CC[C@@H](C3)O)C(=O)NCC4CC4)C5=CC=CC=C5

LEI-401（Cat No.:I015142）is a selective, brain-penetrant small-molecule antagonist of the nuclear receptor REV-ERBα, a key regulator of circadian rhythm and metabolic processes. By blocking REV-ERBα activity, LEI-401 modulates transcriptional networks controlling lipid metabolism, glucose homeostasis, and inflammatory signaling. It has been widely used in research to explore the interplay between circadian regulation and metabolic or immune disorders. With its ability to cross the blood–brain barrier, LEI-401 is particularly valuable in neuroscience and endocrinology, providing insights into novel therapeutic strategies for sleep, mood, and metabolic diseases.