LED209

• CAT Number: I002829
• CAS Number: 245342-14-7
• Molecular Formula: C19H17N3O2S2
• Molecular Weight: 383.5
• Purity: ≥95%
• Synonyms: (Z)-N/’-phenyl-N-(4-(N-phenylsulfamoyl)phenyl)carbamimidothioic acid
• Target: Histamine
• Solubility: DMSO: ＜ 3.8 mg/mL
• Storage: 2-8°C
• IUPAC Name: 1-phenyl-3-[4-(phenylsulfamoyl)phenyl]thiourea
• InChI: InChI=1S/C19H17N3O2S2/c23-26(24,22-17-9-5-2-6-10-17)18-13-11-16(12-14-18)21-19(25)20-15-7-3-1-4-8-15/h1-14,22H,(H2,20,21,25)
• InChIKey: HNDRSTUKPCLQLT-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)NC(=S)NC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3

LED209（Cat No.:I002829） is a powerful small molecule inhibitor specifically designed to target the bacterial receptor QseC. It acts as a potent prodrug that exhibits high selectivity for QseC. By inhibiting QseC, LED209 disrupts the signaling pathways involved in bacterial virulence and pathogenesis. This inhibition can potentially lead to the attenuation of bacterial infections and the development of novel antibacterial strategies.

Reference

[1]. Curtis MM, et al. QseC inhibitors as an antivirulence approach for Gram-negative pathogens. MBio. 2014 Nov 11;5(6):e02165.

[2]. Harrison CF, et al. Adrenergic antagonists restrict replication of Legionella. Microbiology. 2015 Jul;161(7):1392-406.

[3]. Rasko DA, et al. Targeting QseC signaling and virulence for antibiotic development. Science. 2008 Aug 22;321(5892):1078-80.