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LDN-214117

LDN-214117

  • CAT Number: I002097
  • CAS Number: 1627503-67-6
  • Molecular Formula: C25H29N3O3
  • Molecular Weight: 419.5
  • Purity: ≥95%
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LDN-214117 (Cat.No:I002097) is a small molecule inhibitor that targets the transforming growth factor-beta (TGF-β) receptor type I kinase. It selectively inhibits TGF-β receptor activation, thereby blocking downstream signaling pathways involved in tumor growth and metastasis. LDN-214117 has shown potential as an anticancer agent and is being studied for its therapeutic applications in cancer treatment.

Catalog Number I002097
CAS Number 1627503-67-6
Molecular Formula

C25H29N3O3

Purity 95%
Target ALK
Solubility 10 mM in DMSO
Storage Store at -20°C
IC50 22 nM(ALK2) [1]
InChIKey BHUXVRVMMYAXKN-UHFFFAOYSA-N
Reference

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<br>[1]. Mohedas AH, et al. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15.
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