Lck inhibitor 2

• CAT Number: I005622
• CAS Number: 944795-06-6
• Molecular Formula: C18H17N5O2
• Molecular Weight: 335.367
• Purity: ≥95%
• Synonyms: 3-[[4-(5-hydroxy-2-methylanilino)pyrimidin-2-yl]amino]benzamide
• Target: Src
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 13 nM(Lck)
• InChI: InChI=1S/C18H17N5O2/c1-11-5-6-14(24)10-15(11)22-16-7-8-20-18(23-16)21-13-4-2-3-12(9-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)
• InChIKey: SFCBIFOAGRZJNX-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)O)NC2=NC(=NC=C2)NC3=CC=CC(=C3)C(=O)N

Lck inhibitor 2 (Cat No.:I005622) is a multi-target tyrosine kinase inhibitor that includes Lck, Btk, Lyn, Btk and Txk with IC50s of 13nM, 9nM, 3nM, 26nM and 2nM, respectively.

 

Reference

[1]. Bamborough, et al. Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery. Journal of Medicinal Chemistry (2008), 51(24), 7898-7914. 


[2]. Bamborough, Paul, et al. N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics. Bioorganic & Medicinal Chemistry Letters (2007), 17(15), 4363-4368.


[3]. Awale, Mahendra, et al. Molecular docking guided 3D-QSAR CoMFA analysis of N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of leukocyte-specific protein tyrosine kinase. Journal of Molecular Modeling (2008), 14(10), 937-947.