Lauric Acid

• CAT Number: R023562
• CAS Number: 143-07-7
• Molecular Formula: C12H24O2
• Molecular Weight: 200.322
• Purity: ≥95%
• Target: Lipid Metabolism
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: dodecanoic acid
• InChI: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
• InChIKey: POULHZVOKOAJMA-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCCC(=O)O

Lauric acid also known as Dodecanoic Acid and GT-08, is a proton pump inhibitor potentially for the treatment of helicobacter pylori infections. In vitro experiments have suggested that some fatty acids including lauric acid could be a useful component in a treatment for acne, but no clinical trials have yet been conducted to evaluate this potential benefit in humans. Lauric acid increases total serum cholesterol more than many other fatty acids. But most of the increase is attributable to an increase in high-density lipoprotein (HDL) (the "good" blood cholesterol). As a result, lauric acid has been characterized as having "a more favorable effect on total HDL cholesterol than any other fatty acid, either saturated or unsaturated.

Reference

1:Lauric acid as feed additive – An approach to reducing Campylobacter spp. in broiler meat. Zeiger K, Popp J, Becker A, Hankel J, Visscher C, Klein G, Meemken D.PLoS One. 2017 Apr 18;12(4):e0175693. doi: 10.1371/journal.pone.0175693. eCollection 2017. PMID: 28419122 Free PMC Article2:Enteric methane production in lactating dairy cows with continuous feeding of essential oils or rotational feeding of essential oils and lauric acid. Klop G, Dijkstra J, Dieho K, Hendriks WH, Bannink A.J Dairy Sci. 2017 May;100(5):3563-3575. doi: 10.3168/jds.2016-12033. Epub 2017 Feb 23. PMID: 28237592 3:Antibacterial efficacy of triple-layered poly(lactic-co-glycolic acid)/nanoapatite/lauric acid guided bone regeneration membrane on periodontal bacteria. Saarani NN, Jamuna-Thevi K, Shahab N, Hermawan H, Saidin S.Dent Mater J. 2017 Jan 20. doi: 10.4012/dmj.2016-177. [Epub ahead of print] PMID: 28111388 Free Article4:Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats. Alves NF, de Queiroz TM, de Almeida Travassos R, Magnani M, de Andrade Braga V.Basic Clin Pharmacol Toxicol. 2017 Apr;120(4):348-353. doi: 10.1111/bcpt.12700. Epub 2017 Jan 5. PMID: 28054477 5:Lauric Acid Stimulates Mammary Gland Development of Pubertal Mice through Activation of GPR84 and PI3K/Akt Signaling Pathway. Meng Y, Zhang J, Zhang F, Ai W, Zhu X, Shu G, Wang L, Gao P, Xi Q, Zhang Y, Liang X, Jiang Q, Wang S.J Agric Food Chem. 2017 Jan 11;65(1):95-103. doi: 10.1021/acs.jafc.6b04878. Epub 2016 Dec 22. PMID: 27978622 6:Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis. Han S, Pham TV, Kim JH, Lim YR, Park HG, Jeong D, Yun CH, Chun YJ, Kang LW, Kim D.Biochem Biophys Res Commun. 2017 Jan 22;482(4):902-908. doi: 10.1016/j.bbrc.2016.11.131. Epub 2016 Nov 25. PMID: 27890614 7:In Silico and Wet Lab Studies Reveal the Cholesterol Lowering Efficacy of Lauric Acid, a Medium Chain Fat of Coconut Oil. Lekshmi Sheela D, Nazeem PA, Narayanankutty A, Manalil JJ, Raghavamenon AC.Plant Foods Hum Nutr. 2016 Dec;71(4):410-415. PMID: 27679437 8:Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity. McCarty MF, DiNicolantonio JJ.Open Heart. 2016 Jul 27;3(2):e000467. doi: 10.1136/openhrt-2016-000467. eCollection 2016. Review. PMID: 27547436 Free PMC Article9:Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid ω-hydroxylase expressed in liver and kidney tissues. Uehara S, Uno Y, Ishii S, Inoue T, Sasaki E, Yamazaki H.Xenobiotica. 2017 Jul;47(7):553-561. doi: 10.1080/00498254.2016.1206673. Epub 2016 Jul 20. PMID: 27435360 10:Lauric Acid Stimulates Ketone Body Production in the KT-5 Astrocyte Cell Line. Nonaka Y, Takagi T, Inai M, Nishimura S, Urashima S, Honda K, Aoyama T, Terada S.J Oleo Sci. 2016 Aug 1;65(8):693-9. doi: 10.5650/jos.ess16069. Epub 2016 Jul 15. PMID: 27430387 Free Article