L-Thioproline

• CAT Number: R022864
• CAS Number: 34592-47-7
• Molecular Formula: C4H7NO2S
• Molecular Weight: 133.165
• Purity: ≥95%
• Storage: Store at RT
• IUPAC Name: (4R)-1,3-thiazolidine-4-carboxylic acid
• InChI: InChI=1S/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m0/s1
• InChIKey: DZLNHFMRPBPULJ-VKHMYHEASA-N
• SMILES: C1C(NCS1)C(=O)O

Timonacic is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities. Acting on cellular membranes of malignant cells through an unknown mechanism, timonacic may induce malignant cells to revert back to an untransformed state. This agent may also restore contact inhibition, a phenomenon characterized by the paracrine inhibition of mitosis following the formation of a critical cell mass, presumably the result of cell-to-cell signal transfer. Timonacic may also produce antioxidant effects secondary to its release of cysteine and restoration of glutathione concentrations.

Reference

1:Effect of L-thioproline on the progression and events of the cell cycle of HeLa cells. García Cañero R, López-Alarcón L, Veloso JJ, del Carmen Guijarro M.Int J Cancer. 1988 Jun 15;41(6):859-62. PMID: 2836319 2:A new type of N-nitrosamino acid, N-nitroso-L-thioproline and N-nitroso-L-methylthioprolines, found in human urine as major N-nitroso compounds. Tsuda M, Hirayama T, Sugimura T, Kakizoe T.IARC Sci Publ. 1984;(57):87-94. PMID: 6533071 3:Presence of N-nitroso-L-thioproline and N-nitroso-L-methylthioprolines in human urine as major N-nitroso compounds. Tsuda M, Hirayama T, Sugimura T.Gan. 1983 Jun;74(3):331-3. PMID: 6884690