L-SEPIAPTERIN

• CAT Number: M076962
• CAS Number: 17094-01-8
• Molecular Formula: C9H11N5O3
• Molecular Weight: 237.219
• Purity: ≥95%
• Storage: Store at -20C
• IUPAC Name: 2-amino-6-[(2S)-2-hydroxypropanoyl]-7,8-dihydro-1H-pteridin-4-one
• InChI: InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,15H,2H2,1H3,(H4,10,11,13,14,17)/t3-/m0/s1
• InChIKey: VPVOXUSPXFPWBN-VKHMYHEASA-N
• SMILES: CC(C(=O)C1=NC2=C(NC1)NC(=NC2=O)N)O

L-SEPIAPTERIN (CAS 17094-01-8) is an important intermediate in the pterin salvage pathway, tetrahydropterin biosynthesis. Sepiapterin improved the endothelial dysfunction in SMA from db​/db mice by decreasing oxidative stress. Sepiapterin is commonly used in the study for treamtment of Type I Diabetes.

Reference

1.Madsen, Jakob Torp, et al. "Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1‐methyl‐4‐phenylpyridinium in nigral slice cultures." Journal of neurochemistry 85.1 (2003): 214-223.
2.Gramsbergen, Jan Bert, et al. "Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin." Brain research 935.1-2 (2002): 47-58.
3.Sung, Yen-Jen, Joseph H. Hotchkiss, and Rodney R. Dieteri. "2, 4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages." International journal of immunopharmacology 16.2 (1994): 101-108.
4.Pannirselvam, Malarvannan, et al. "Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice." British journal of pharmacology 140.4 (2003): 701-706.