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L-778123 hydrochloride

L-778123 hydrochloride

  • CAT Number: I002867
  • CAS Number: 253863-00-2
  • Molecular Formula: C₂₂H₂₀ClN₅O
  • Molecular Weight: 405.88
  • Purity: ≥95%
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L-778123 hydrochloride(CAT: I002867) is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.

Catalog Number I002867
CAS Number 253863-00-2
Molecular Formula

C₂₂H₂₀ClN₅O

Purity 95%
Target farnesyltransferase inhibitor
Solubility Soluble in DMSO, not in water
Storage -20°C
InChI InChI=1S/C22H20ClN5O.ClH/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18;/h1-7,10,12,16H,8-9,13-15H2;1H
InChIKey YNBSQYGTJLIPJS-UHFFFAOYSA-N
SMILES C1CN(C(=O)CN1CC2=CN=CN2CC3=CC=C(C=C3)C#N)C4=CC(=CC=C4)Cl.Cl
Reference

1: Ghasemi S, Davaran S, Sharifi S, Asgari D, Abdollahi A, Shahbazi Mojarrad J.
Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and
Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-7.
doi: 10.5681/apb.2013.012. Epub 2013 Feb 7. PubMed PMID: 24312815; PubMed Central
PMCID: PMC3846042.

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