For research use only. Not for therapeutic Use.
L-745870 hydrochloride(CAT: I017523) is a potent and highly selective dopamine D4 receptor antagonist (Ki = 0.43 nM) with excellent brain penetration and oral bioavailability. It exhibits substantially weaker affinity for D2 and D3 receptors, and moderate activity at 5-HT2 receptors, sigma sites, and α-adrenoceptors. Functionally, L-745870 blocks D4 receptor–mediated inhibition of adenylate cyclase activity, calcium currents, and G protein–coupled inwardly rectifying K⁺ channels, as well as extracellular acidification responses in transfected cells. Pharmacokinetic studies show favorable half-life (2.1–2.8 h) and high brain-to-plasma ratios. In vivo, it induces mild sedation at higher doses, supporting its utility in dopaminergic research.
| CAS Number | 1173023-36-3 |
| Synonyms | 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine;hydrochloride |
| Molecular Formula | C18H20Cl2N4 |
| Purity | ≥95% |
| IUPAC Name | 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine;hydrochloride |
| InChI | InChI=1S/C18H19ClN4.ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;/h1-7,12H,8-11,13H2,(H,20,21);1H |
| InChIKey | GFFJYISJZJIKAF-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CC2=CNC3=C2C=CC=N3)C4=CC=C(C=C4)Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
