L-67

• CAT Number: I003153
• CAS Number: 325970-71-6
• Molecular Formula: C₁₆H₁₄Br₂N₄O₄
• Molecular Weight: 486.11
• Purity: ≥95%
• Target: DNA ligases
• Solubility: DMSO: ≥ 33 mg/mL
• Storage: Store at -20°C
• IC50: 10 μM
• IUPAC Name: 2-(3,5-dibromo-4-methylanilino)-N-[(E)-(2-hydroxy-5-nitrophenyl)methylideneamino]acetamide
• InChI: InChI=1S/C16H14Br2N4O4/c1-9-13(17)5-11(6-14(9)18)19-8-16(24)21-20-7-10-4-12(22(25)26)2-3-15(10)23/h2-7,19,23H,8H2,1H3,(H,21,24)/b20-7+
• InChIKey: KFEPVFJQVOMODD-IFRROFPPSA-N
• SMILES: CC1=C(C=C(C=C1Br)NCC(=O)NN=CC2=C(C=CC(=C2)[N+](=O)[O-])O)Br

L67 (Cat No. : I003153) is a new DNA ligase inhibitor that competes with high potency against DNA ligase I and III, displaying an IC50 of 10 μM. Its unique mechanism makes it an intriguing prospect for DNA-related research and therapeutic applications. If you require further information or have any specific inquiries, please reach out to us. Our dedicated team will respond promptly within 24 hours to assist you.

Reference

1:The anti-allergic activity of Lactobacillus plantarum L67 and its application to yogurt. Song S, Lee SJ, Park DJ, Oh S, Lim KT.J Dairy Sci. 2016 Dec;99(12):9372-9382. doi: 10.3168/jds.2016-11809. Epub 2016 Oct 13. PMID: 27743673 2:Lactobacillus plantarum L67 glycoprotein protects against cadmium chloride toxicity in RAW 264.7 cells. Song S, Oh S, Lim KT.J Dairy Sci. 2016 Mar;99(3):1812-21. doi: 10.3168/jds.2015-10121. Epub 2016 Jan 13. PMID: 26774722 3:Bioactivity of proteins isolated from Lactobacillus plantarum L67 treated with Zanthoxylum piperitum DC glycoprotein. Song S, Oh S, Lim KT.Lett Appl Microbiol. 2015 Jun;60(6):597-604. doi: 10.1111/lam.12416. Epub 2015 Apr 8. PMID: 25773674 4:The proteins (12 and 15 kDa) isolated from heat-killed Lactobacillus plantarum L67 induces apoptosis in HT-29 cells. Song S, Oh S, Lim KT.Cell Biochem Funct. 2015 Mar;33(2):89-96. doi: 10.1002/cbf.3094. Epub 2015 Feb 20. PMID: 25703965 5:Cold stress improves the ability of Lactobacillus plantarum L67 to survive freezing. Song S, Bae DW, Lim K, Griffiths MW, Oh S.Int J Food Microbiol. 2014 Nov 17;191:135-43. doi: 10.1016/j.ijfoodmicro.2014.09.017. Epub 2014 Sep 18. PMID: 25261832 6:Mutation of single hydrophobic residue I27, L35, F39, L58, L65, L67, or L71 in the N terminus of VP5 abolishes interaction with the scaffold protein and prevents closure of herpes simplex virus type 1 capsid shells. Walters JN, Sexton GL, McCaffery JM, Desai P.J Virol. 2003 Apr;77(7):4043-59. PMID: 12634364 Free PMC Article7:The role of the M6-M7 loop (L67) in stabilization of the phosphorylation and Ca(2+) binding domains of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA). Zhang Z, Lewis D, Sumbilla C, Inesi G, Toyoshima C.J Biol Chem. 2001 May 4;276(18):15232-9. Epub 2001 Feb 5. PMID: 11278755 Free Article8:[Clinical use of citanest (L67, Astra)]. Suzuki H.Masui. 1965 Feb;14(2):159-65. Japanese. No abstract available. PMID: 5892535 9:[Citanest (L67)–a new local anesthetic]. von BAHR, ERIKSSON E.Sven Lakartidn. 1962 Aug 2;59:2221-32. Swedish. No abstract available. PMID: 13863977