For research use only. Not for therapeutic Use.
L-372662（Cat No.:I007555）is a potent, non-peptide antagonist of the neurokinin-1 (NK1) receptor, with high affinity for both human and guinea pig NK1 receptors. It effectively inhibits substance P-mediated responses and is used primarily in research focused on neuroinflammation, pain, depression, and emesis. L-372662 exhibits good oral bioavailability and blood-brain barrier penetration, making it suitable for in vivo studies targeting central nervous system pathways. Its selective NK1 antagonism makes it a valuable tool for dissecting the role of substance P in various neurological and psychiatric disorders, including stress-related pathologies and nausea.
| CAS Number | 162045-26-3 |
| Synonyms | 1-[1-[2-methoxy-4-[1-[(2-methyl-1-oxidopyridin-1-ium-3-yl)methyl]piperidin-4-yl]oxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one |
| Molecular Formula | C33H38N4O6 |
| Purity | ≥95% |
| IUPAC Name | 1-[1-[2-methoxy-4-[1-[(2-methyl-1-oxidopyridin-1-ium-3-yl)methyl]piperidin-4-yl]oxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one |
| InChI | InChI=1S/C33H38N4O6/c1-23-24(7-5-15-36(23)40)21-34-16-13-27(14-17-34)43-28-9-10-29(31(20-28)41-2)32(38)35-18-11-26(12-19-35)37-30-8-4-3-6-25(30)22-42-33(37)39/h3-10,15,20,26-27H,11-14,16-19,21-22H2,1-2H3 |
| InChIKey | SKWSXDUHUVMPBT-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC=[N+]1[O-])CN2CCC(CC2)OC3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5C6=CC=CC=C6COC5=O)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
