BAN-ORL-24 HCl

• CAT Number: I003943
• CAS Number: 1401463-54-4 (HCl)
• Molecular Formula: C27H37Cl2N3O2
• Molecular Weight: 506.512
• Purity: ≥95%
• Target: KOR-3 (NOP) antagonist
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term or -20 °C for long term
• IUPAC Name: (2R)-1-benzyl-N-(3-spiro[1H-2-benzofuran-3,4/'-piperidine]-1/'-ylpropyl)pyrrolidine-2-carboxamide;dihydrochloride
• InChI: InChI=1S/C27H35N3O2.2ClH/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27;;/h1-5,8-11,25H,6-7,12-21H2,(H,28,31);2*1H/t25-;;/m1../s1
• InChIKey: NEEVITHVDIQNJY-KHZPMNTOSA-N
• SMILES: C1CC(N(C1)CC2=CC=CC=C2)C(=O)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4.Cl.Cl

BAN-ORL-24 is a Potent and selective NOP receptor antagonist. NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids.

Reference

1:Effects of Clove Oil and Lidocaine-HCl Anesthesia on Water Parameter during Simulated Transportation in the Marine Medaka, Oryzias dancena. Park IS, Gil HW, Lee TH, Nam YK, Lim SG, Kim DS.Dev Reprod. 2017 Mar;21(1):19-33. doi: 10.12717/DR.2017.21.1.019. Epub 2017 Mar 31. PMID: 28484741 Free PMC Article2:Olive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities. Al-Quraishy S, Othman MS, Dkhil MA, Abdel Moneim AE.Biomed Pharmacother. 2017 Apr 29;91:338-349. doi: 10.1016/j.biopha.2017.04.069. [Epub ahead of print] PMID: 28463797 3:HCl dissociating on a rigid Au(111) surface: A six-dimensional quantum mechanical study on a new potential energy surface based on the RPBE functional. Liu T, Fu B, Zhang DH.J Chem Phys. 2017 Apr 28;146(16):164706. doi: 10.1063/1.4982051. PMID: 28456190 4:A new ab initio potential energy surface of LiClH (1A/’) system and quantum dynamics calculation for Li + HCl (v = 0, j = 0-2) → LiCl + H reaction. Tan RS, Zhai HC, Yan W, Gao F, Lin SY.J Chem Phys. 2017 Apr 28;146(16):164305. doi: 10.1063/1.4982066. PMID: 28456188 5:Spectroscopic Characterization of the Reaction Products between the Criegee Intermediate CH2 OO and HCl. Cabezas C, Endo Y.Chemphyschem. 2017 Apr 27. doi: 10.1002/cphc.201700446. [Epub ahead of print] PMID: 28449411 6:Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl. El Nabarawi MA, Teaima MH, Abd El-Monem RA, El Nabarawy NA, Gaber DA.Drug Des Devel Ther. 2017 Apr 3;11:1081-1093. doi: 10.2147/DDDT.S131936. eCollection 2017. PMID: 28435220 Free PMC Article7:Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent-Meclizine HCl. Qazi F, Shoaib MH, Yousuf RI, Nasiri MI, Ahmed K, Ahmad M.Lipids Health Dis. 2017 Apr 12;16(1):75. doi: 10.1186/s12944-017-0466-x. PMID: 28403892 Free PMC Article8:Acute exposure of primary rat soleus muscle to zilpaterol HCl (β2 adrenergic agonist), TNFα, or IL-6 in culture increases glucose oxidation rates independent of the impact on insulin signaling or glucose uptake. Cadaret CN, Beede KA, Riley HE, Yates DT.Cytokine. 2017 Apr 5;96:107-113. doi: 10.1016/j.cyto.2017.03.014. [Epub ahead of print] PMID: 28390265 9:Effects of anabolic implants and ractopamine-HCl on muscle fiber morphometrics, collagen solubility, and tenderness of beef longissimus lumborum steaks. Ebarb SM, Phelps KJ, Drouillard JS, Maddock-Carlin KR, Vaughn MA, Burnett DD, Noel JA, Van Bibber-Krueger CL, Paulk CB, Grieger DM, Gonzalez JM.J Anim Sci. 2017 Mar;95(3):1219-1231. doi: 10.2527/jas.2016.1263. PMID: 28380530 10:Comparative plasma and tissue distribution of Sun Pharma/’s generic doxorubicin HCl liposome injection versus Caelyx® (doxorubicin HCl liposome injection) in syngeneic fibrosarcoma-bearing BALB/c mice and Sprague-Dawley rats. Burade V, Bhowmick S, Maiti K, Zalawadia R, Jain D, Rajamannar T.Cancer Chemother Pharmacol. 2017 May;79(5):899-913. doi: 10.1007/s00280-017-3278-9. Epub 2017 Mar 27. PMID: 28349166 Free PMC Article