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L-189

L-189

  • CAT Number: I004427
  • CAS Number: 64232-83-3
  • Molecular Formula: C₁₁H₁₀N₄OS
  • Molecular Weight: 246.29
  • Purity: ≥95%
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<p style=/line-height:25px/>L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.<br>IC50 value: 5/9/5 μM (for hLigI/III/IV)<br>Target: DNA ligase<br>in vitro: L189 is a competitive inhibitor with respect to nicked DNA. L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non-homologous end joinging. L189 markedly increases killing of HCT116 colon cancer cells and the other cancer cell lines by ionizing radiation.</p>

Catalog Number I004427
CAS Number 64232-83-3
Molecular Formula

C₁₁H₁₀N₄OS

Purity 95%
Target DNA Ligases
Solubility DMSO: ≥ 33 mg/mL
Storage Store at -20C
IC50 5/9/5 μM (for hLigI/III/IV)
InChI InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)
InChIKey SAKOXVNKDMWWLF-UHFFFAOYSA-N
SMILES C1=CC=C(C=C1)C=NC2=C(NC(=S)NC2=O)N
Reference

<p style=/line-height:25px/>
<br>[1]. Xi Chen, Shijun Zhong, Xiao Zhu, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008
</p>

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