For research use only. Not for therapeutic Use.
KY19382 (Cat No.: I045458) is a small-molecule activator of the Wnt/β-catenin signaling pathway, primarily acting by inhibiting CXXC-type zinc finger protein 5 (CXXC5)–Dvl interaction, which negatively regulates Wnt signaling. By enhancing β-catenin–mediated transcription, KY19382 promotes cell proliferation, differentiation, and tissue regeneration. It has been investigated for applications in wound healing, hair regeneration, and regenerative medicine. KY19382 serves as a valuable research tool for studying Wnt pathway modulation and exploring therapeutic strategies targeting tissue repair, stem cell activation, and diseases linked to impaired Wnt signaling.
| CAS Number | 2226664-93-1 |
| Synonyms | 5,6-dichloro-3-[(3Z)-3-methoxyiminoindol-2-yl]-1H-indol-2-ol |
| Molecular Formula | C17H11Cl2N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H11Cl2N3O2/c1-24-22-15-8-4-2-3-5-12(8)20-16(15)14-9-6-10(18)11(19)7-13(9)21-17(14)23/h2-7,21,23H,1H3/b22-15- |
| InChIKey | TVZDUDDLASVAOM-JCMHNJIXSA-N |
| SMILES | CON=C1C2=CC=CC=C2N=C1C3=C(NC4=CC(=C(C=C43)Cl)Cl)O |
| Reference | [1]. Choi S, et, al. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth. Life Sci Alliance. 2019 Apr 10; 2(2): e201800254. [2]. Choi KY, et, al. Compositions and methods for suppressing and/or treating metabolic diseases and/or a clinical condition thereof. WO2020079569. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
