KU-60019

• CAT Number: I005509
• CAS Number: 925701-46-8
• Molecular Formula: C30H33N3O5S
• Molecular Weight: 547.67
• Purity: ≥95%
• Target: ATM
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: -20°C
• IC50: 6.3 nM
• IUPAC Name: 2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-N-[5-(6-morpholin-4-yl-4-oxopyran-2-yl)-9H-thioxanthen-2-yl]acetamide
• InChI: InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+
• InChIKey: SCELLOWTHJGVIC-BGYRXZFFSA-N
• SMILES: CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C=CC=C4C3)C5=CC(=O)C=C(O5)N6CCOCC6

KU-60019 (Cat.No:I005509) is a potent and selective inhibitor of the DNA-dependent protein kinase (DNA-PK). It inhibits the catalytic activity of DNA-PK, an enzyme involved in the repair of double-strand DNA breaks. KU-60019 is commonly used in research to study DNA damage response and to investigate the role of DNA-PK in cellular processes such as DNA repair and apoptosis.

Reference

[1]. Golding SE et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.


[2]. Golding SE, Rosenberg E, Adams BR, Wignarajah S, Beckta JM, O/’Connor MJ, Valerie K.Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control.Cell Cycle. 2012 Mar 15;11(6):1167-73. Epub 2012 Mar 15.


[3]. Raso A, Vecchio D, Cappelli E, Ropolo M, Poggi A, Nozza P, Biassoni R, Mascelli S, Capra V, Kalfas F, Severi P, Frosina G.Characterization of Glioma Stem Cells Through Multiple Stem Cell Markers and Their Specific Sensitization to Double-Strand Break-Inducing Agents by Pharmacological Inhibition of Ataxia Telangiectasia Mutated Protein.Brain Pathol. 2012 Sep;22(5):677-688.