KT5823

• CAT Number: R014639
• CAS Number: 126643-37-6
• Molecular Formula: C₂₉H₂₅N₃O₅
• Molecular Weight: 495.53
• Purity: ≥95%
• Target: Protein Kinase G
• Solubility: Soluble in DMSO > 10 mM
• Storage: Desiccate at -20C
• InChI: InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3
• InChIKey: QTYMDECKVKSGSM-UHFFFAOYSA-N
• SMILES: CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CN(C6=O)C)(C(=O)OC)OC

KT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). KT 5823 inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.

Reference

1: Smolenski A, Burkhardt AM, Eigenthaler M, Butt E, Gambaryan S, Lohmann SM, Walter U. Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jul;358(1):134-9. Review. PubMed PMID: 9721015.