KJ Pyr 9

• CAT Number: I004168
• CAS Number: 581073-80-5
• Molecular Formula: C22H15N3O4
• Molecular Weight: 385.4
• Purity: ≥95%
• Target: c-Myc
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 6.5 ± 1.0 nM (Kd)
• InChIKey: GTTDVYCKFQYVNN-UHFFFAOYSA-N

KJ Pyr 9 (CAT: I004168) is a novel small-molecule inhibitor of MYC, a transcription factor that plays a critical role in cancer development and progression. KJ-Pyr-9 specifically targets MYC and interferes with its function both in vitro and in vivo. In vitro studies have shown that KJ-Pyr-9 inhibits MYC-induced oncogenic transformation and disrupts MYC-MAX complex formation, which is essential for MYC-mediated transcriptional regulation. KJ-Pyr-9 preferentially affects the proliferation of MYC-overexpressing cells and reduces the MYC-driven transcriptional signature. Furthermore, it inhibits apoptosis-associated cleaved caspase 3 and can dissociate the intact MYC-MAX complex.

Reference

[1]. Hart JR, et al. Inhibitor of MYC identified in a Kr?hnke pyridine library. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12556-61.

[2]. Raffeiner P, et al. In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential. Oncotarget. 2014 Oct 15;5(19):8869-78.

[3]. Novel molecule hits key cancer target. Cancer Discov. 2014 Nov;4(11):OF8.