Ki 8751

  • CAT Number: I002742
  • CAS Number: 228559-41-9
  • Molecular Formula: C24H18F3N3O4
  • Molecular Weight: 469.42
  • Purity: ≥95%
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Ki 8751 (Cat.No:I002742) is a potent and selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), a receptor involved in angiogenesis and tumor growth. By blocking VEGFR2 signaling, Ki 8751 inhibits the formation of new blood vessels and suppresses tumor growth. This compound holds promise as a therapeutic agent for various angiogenesis-related diseases, including cancer.

Catalog Number I002742
CAS Number 228559-41-9
Molecular Formula

C24H18F3N3O4

Purity 95%
Target VEGFR
Solubility DMSO ≥92mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
Storage 3 years -20C powder
IC50 0.9 nM [1]
IUPAC Name 1-(2,4-difluorophenyl)-3-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]urea
InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
InChIKey LFKQSJNCVRGFCC-UHFFFAOYSA-N
SMILES COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F
Reference

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<br>[1]. Kubo K, et al. Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N/’-{4-(4-quinolyloxy)phenyl}ureas. J Med Chem, 2005, 48(5), 1359-1366.
<br>[2]. Tamura D, et al. Bortezomib potentially inhibits cellular growth of vascular endothelial cells through suppression of G2/M transition. Cancer Sci, 2010, 101(6), 1403-1408.
<br>[3]. Hasan MR, et al. Inhibition of VEGF induces cellular senescence in colorectal cancer cells. Int J Cancer, 2011, 129(9), 2115–2123.
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