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Ketotifen

Ketotifen

  • CAT Number: I030054
  • CAS Number: 34580-13-7
  • Molecular Formula: C19H19NOS
  • Molecular Weight: 309.43
  • Purity: 98%
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Ketotifen(CAT: I030054) is a medication used for the treatment of allergic conditions such as asthma, allergic rhinitis, and atopic dermatitis. Ketotifen works by blocking the release of certain chemicals in the body that are involved in the allergic response. This helps to reduce inflammation and alleviate symptoms such as itching, sneezing and wheezing.

Catalog Number I030054
CAS Number 34580-13-7
Molecular Formula

C19H19NOS

Purity 98
Solubility To be determined
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-
InChI InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3
InChIKey ZCVMWBYGMWKGHF-UHFFFAOYSA-N
SMILES CN1CCC(=C2c3ccccc3CC(=O)c4sccc24)CC1
Reference

1: Schwarzer G, Bassler D, Mitra A, Ducharme FM, Forster J. Ketotifen alone or as additional medication for long-term control of asthma and wheeze in children. Cochrane Database Syst Rev. 2004;(1):CD001384. Review. PubMed PMID: 14973969.
2: Pérez-Padilla JR. [Ketotifen (Zaditen and K-Asthmal): a drug with sales disproportionate to its demonstrated effectiveness]. Gac Med Mex. 1999 Mar-Apr;135(2):165-70. Review. Spanish. PubMed PMID: 10327750.
3: Grant SM, Goa KL, Fitton A, Sorkin EM. Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders. Drugs. 1990 Sep;40(3):412-48. Review. Erratum in: Drugs 1991 Feb;41(2):192. PubMed PMID: 2226222.
4: Oehling A, Castillo JG, Gamboa PM. Membrane IgE and adenyl cyclase activity in the dynamics of bronchospasm. Ketotifen as a blocker of antigen action. Allergol Immunopathol (Madr). 1990 Jul-Aug;18(4):237-40. Review. PubMed PMID: 1702264.
5: Nowak D, Magnussen H. [Ketotifen (Zaditen) and disodium cromoglycinic acid (Intal) in the therapy of bronchial asthma]. Prax Klin Pneumol. 1987 Sep;41(9):319-23. Review. German. PubMed PMID: 3124092.
6: Craps L. Prophylaxis of asthma with ketotifen in children and adolescents: a review. Pharmatherapeutica. 1983;3(5):314-26. Review. PubMed PMID: 6405397.
7: Craps L. [Ketotifen in the prevention of bronchial asthma. International therapeutic evaluation]. Allergol Immunopathol (Madr). 1981;Suppl 9:177-90. Review. French. PubMed PMID: 6131598.
8: Doligalska M. [Effect of ketotifen on the immune response in BALB/c mice infected with Trichinella spiralis]. Wiad Parazytol. 2000;46(2):217-24. Review. Polish. PubMed PMID: 16886340.
9: Paquette D, Rothe MJ. Unapproved dermatologic indications for H2 receptor antagonists, cromolyn sodium, and ketotifen. Clin Dermatol. 2000 Jan-Feb;18(1):103-11. Review. PubMed PMID: 10701091.
10: Mancel E, Drouet M, Sabbah A. [Membrane stabilizers (chromones and ketotifen)]. Allerg Immunol (Paris). 1999 Apr;31(4):103-5. Review. French. PubMed PMID: 10370721.
11: Govil YC, Misra PK. Ketotifen. Indian Pediatr. 1992 Jan;29(1):85-9. Review. PubMed PMID: 1601503.
12: Lieberman D, Lieberman D. [Prophylaxis of bronchial asthma–disodium cromoglycate and ketotifen]. Harefuah. 1987 May 1;112(9):462-6. Review. Hebrew. PubMed PMID: 3117649.
13: Warner JO, Goldsworthy SJ. Ketotifen in childhood allergic disease. Clin Allergy. 1982 Oct;12 Suppl:21-7. Review. PubMed PMID: 6814787.
14: Craps L. Ketotifen in the oral prophylaxis of bronchial asthma: a review. Pharmatherapeutica. 1981;3(1):18-35. Review. PubMed PMID: 6119703.

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