• CAT Number: A000609
  • CAS Number: 22071-15-4
  • Molecular Formula: C16H14O3
  • Molecular Weight: 254.3
  • Purity: ≥95%
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Ketoprofen is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic effects. It acts by inhibiting the body/’s production of prostaglandin.

Catalog Number A000609
CAS Number 22071-15-4

22071-15-4; 2-(3-Benzoylphenyl)propanoic acid; Orudis; 2-(3-Benzoylphenyl)propionic acid; M-Benzoylhydratropic acid

Molecular Formula


Purity 95%
Target COX
Solubility Soluble in DMSO > 10 mM
Storage -20°C
InChI 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

1: Toledo MV, Briand LE. Relevance and bio-catalytic strategies for the kinetic
resolution of ketoprofen towards dexketoprofen. Crit Rev Biotechnol. 2017 Nov
10:1-23. doi: 10.1080/07388551.2017.1399249. [Epub ahead of print] PubMed PMID:

2: Lobo S, Yan G. Improving the direct penetration into tissues underneath the
skin with iontophoresis delivery of a ketoprofen cationic prodrug. Int J Pharm.
2017 Nov 14;535(1-2):228-236. doi: 10.1016/j.ijpharm.2017.10.061. [Epub ahead of
print] PubMed PMID: 29104055.

3: Thompson KA, Papich MG, Higgins B, Flanagan J, Christiansen EF, Harms CA.
Ketoprofen pharmacokinetics of R- and S-isomers in juvenile loggerhead sea
turtles (Caretta caretta) after single intravenous and single- and multidose
intramuscular administration. J Vet Pharmacol Ther. 2017 Oct 22. doi:
10.1111/jvp.12460. [Epub ahead of print] PubMed PMID: 29057479.

4: Hirose S, Matsuura K, Kato-Hayashi H, Suzuki A, Ohata K, Kobayashi R, Ibuka T,
Araki H, Shimizu M, Itoh Y. Gastrointestinal bleeding associated with chronic
excessive use overdosing with topical ketoprofen patch in elderly patient. Scand
J Gastroenterol. 2017 Oct 18:1-4. doi: 10.1080/00365521.2017.1390602. [Epub ahead
of print] PubMed PMID: 29043859.

5: Zafar F, Shoaib MH, Yousuf RI, Ali H, Bushra R. Pharmacokinetic and
bioequivalence studies of fast dispersible ketoprofen tablets in healthy
volunteers. Pak J Pharm Sci. 2017 Jul;30(4):1239-1244. PubMed PMID: 29039320.

6: Feng Y, Song Q, Lv W, Liu G. Degradation of ketoprofen by sulfate
radical-based advanced oxidation processes: Kinetics, mechanisms, and effects of
natural water matrices. Chemosphere. 2017 Dec;189:643-651. doi:
10.1016/j.chemosphere.2017.09.109. Epub 2017 Sep 25. PubMed PMID: 28965059.

7: Eljezi V, Biboulet C, Boby H, Schoeffler P, Pereira B, Duale C. The
Dose-Dependent Effects of Ketoprofen on Dynamic Pain after Open Heart Surgery.
Pain Physician. 2017 Sep;20(6):509-520. PubMed PMID: 28934782.

8: Andonova V, Peneva P, Georgiev GS, Toncheva VT, Apostolova E, Peychev Z,
Dimitrova S, Katsarova M, Petrova N, Kassarova M. Ketoprofen-loaded polymer
carriers in bigel formulation: an approach to enhancing drug photostability in
topical application forms. Int J Nanomedicine. 2017 Aug 26;12:6221-6238. doi:
10.2147/IJN.S140934. eCollection 2017. PubMed PMID: 28894363; PubMed Central
PMCID: PMC5584911.

9: Basar AO, Castro S, Torres-Giner S, Lagaron JM, Turkoglu Sasmazel H. Novel
poly(ε-caprolactone)/gelatin wound dressings prepared by emulsion electrospinning
with controlled release capacity of Ketoprofen anti-inflammatory drug. Mater Sci
Eng C Mater Biol Appl. 2017 Dec 1;81:459-468. doi: 10.1016/j.msec.2017.08.025.
Epub 2017 Aug 10. PubMed PMID: 28887998.

10: Osipov AV, Terpinskaya TI, Kuznetsova TE, Ryzhkovskaya EL, Lukashevich VS,
Rudnichenko JA, Ulashchyk VS, Starkov VG, Utkin YN. Cobra Venom Factor and
Ketoprofen Abolish the Antitumor Effect of Nerve Growth Factor from Cobra Venom.
Toxins (Basel). 2017 Sep 6;9(9). pii: E274. doi: 10.3390/toxins9090274. PubMed
PMID: 28878143; PubMed Central PMCID: PMC5618207.

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