Keto Ziprasidone

• CAT Number: I017503
• CAS Number: 884305-07-1
• Molecular Formula: C21H19ClN4O2S
• Molecular Weight: 426.92
• Purity: ≥95%
• Synonyms: 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]acetyl]-6-chloro-1,3-dihydroindol-2-one
• InChI: InChI=1S/C21H19ClN4O2S/c22-16-11-17-13(10-20(28)23-17)9-15(16)18(27)12-25-5-7-26(8-6-25)21-14-3-1-2-4-19(14)29-24-21/h1-4,9,11H,5-8,10,12H2,(H,23,28)
• InChIKey: SJOODKMSLMNGEY-UHFFFAOYSA-N
• SMILES: C1CN(CCN1CC(=O)C2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54

Keto ziprasidone(CAT: I017503) is a key oxidative metabolite of the atypical antipsychotic ziprasidone, formed primarily through aldehyde oxidase–mediated metabolism. While structurally related to the parent compound, keto ziprasidone exhibits reduced activity at dopamine D₂ and serotonin 5-HT₂A receptors compared to ziprasidone, though it may still contribute to the drug’s pharmacological and metabolic profile. Its characterization is important in pharmacokinetic and biotransformation studies, providing insight into ziprasidone’s metabolic pathways, clearance, and interindividual variability in therapeutic response. Keto ziprasidone serves as a reference standard in analytical chemistry, toxicology, and neuropharmacology research for studying the metabolism and safety of atypical antipsychotics.