3’-Hydroxy-amiodarone Hydrochloride

  • CAT Number: C000219
  • CAS Number: 516508-80-8
  • Molecular Formula: C₂₅H₂₉I₂NO₄ • HCl
  • Purity: ≥95%
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3’-Hydroxy-amiodarone Hydrochloride(CAT: C000219) is a metabolite of the drug Amiodarone Hydrochloride. Amiodarone Hydrochloride is a potent antiarrhythmic medication used to treat various types of irregular heart rhythms (arrhythmias). It belongs to class III of antiarrhythmic drugs and works by blocking multiple ion channels involved in the generation of action potentials in cardiac cells, thus helping to maintain a normal heart rhythm. The hydroxylation of amiodarone leads to the formation of 3’-Hydroxy-amiodarone, which is one of its metabolites.

Catalog Number C000219
CAS Number 516508-80-8
Synonyms

[4-[2-(Diethylamino)ethoxy]-3,5-diiodophenyl][2-(3-hydroxybutyl)-3-benzofuranyl]-methanone Hydrochloride;

Molecular Formula

C₂₅H₂₉I₂NO₄ • HCl

Purity 95%
Solubility DMSO (Slightly), Methanol (Slightly)
Storage -20°C, Hygroscopic
Reference

Bonati, M., et al.: J. Pharm. Sci., 73, 829 (1984), Plomp, T.A., Anal. Profiles Drug Subs., 20, 1 (1991), Chow, M., et al.: Ann. Pharmacother., 30, 637 (1996), Singh, B.N., et al.: Clin. Cardiol., 20, 608 (1997) Gao, Y., et al.: Tetrahedron Lett., 54, 6511 (2013); Liao, R., et al.: Proc. Nat. Acad. Sci., 107, 22523 (2010); Miranda, P., et al.: Org. Lett., 5, 1979 (2003); Xu, N., et al.: Macromol. Chem. Phys., 208, 730 (2007)

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