KDU691

• CAT Number: I014421
• CAS Number: 1513879-19-0
• Molecular Formula: C22H18ClN5O2
• Molecular Weight: 419.86
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
• InChI: InChI=1S/C22H18ClN5O2/c1-24-21(29)15-5-3-14(4-6-15)19-11-26-20-12-25-18(13-28(19)20)22(30)27(2)17-9-7-16(23)8-10-17/h3-13H,1-2H3,(H,24,29)
• InChIKey: TYMFFISSODJRDV-UHFFFAOYSA-N
• SMILES: CNC(=O)C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C(=O)N(C)C4=CC=C(C=C4)Cl

KDU691（Cat No.:I014421） is a potent inhibitor of Plasmodium phosphatidylinositol 4-kinase (PI4K). It exhibits IC50 values of 0.18 μM and 0.061 μM against hypnozoite forms and liver schizonts, respectively. KDU691 specifically targets and inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. By disrupting PI4K function, KDU691 impairs parasite development and survival.

Reference

1: Orjuela-Sanchez P, Villa ZH, Moreno M, Tong-Rios C, Meister S, LaMonte GM, Campo B, Vinetz JM, Winzeler EA. Developing Plasmodium vivax Resources for Liver Stage Study in the Peruvian Amazon Region. ACS Infect Dis. 2018 Apr 13;4(4):531-540. doi: 10.1021/acsinfecdis.7b00198. Epub 2018 Mar 15. PubMed PMID: 29542317.2: Dembele L, Ang X, Chavchich M, Bonamy GMC, Selva JJ, Lim MY, Bodenreider C, Yeung BKS, Nosten F, Russell BM, Edstein MD, Straimer J, Fidock DA, Diagana TT, Bifani P. The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. Sci Rep. 2017 May 24;7(1):2325. doi: 10.1038/s41598-017-02440-6. PubMed PMID: 28539634; PubMed Central PMCID: PMC5443816.3: Zeeman AM, Lakshminarayana SB, van der Werff N, Klooster EJ, Voorberg-van der Wel A, Kondreddi RR, Bodenreider C, Simon O, Sauerwein R, Yeung BK, Diagana TT, Kocken CH. PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63. doi: 10.1128/AAC.03080-15. Print 2016 May. PubMed PMID: 26926645; PubMed Central PMCID: PMC4862498.