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Kaurenoic acid

Kaurenoic acid

  • CAT Number: R061212
  • CAS Number: 6730-83-2
  • Molecular Formula: C20H30O2
  • Purity: ≥95%
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<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">Kaurenoic acid (CAS&nbsp;6730-83-2)&nbsp;&nbsp;is a diterpene that has been found in&nbsp;<em>C. langsdorffii </em>and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties.&nbsp;It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC<span style="box-sizing: border-box; position: relative; line-height: 0; vertical-align: baseline; bottom: -0.25em;">50</span>&nbsp;values ranging from 15.03 to 48.87 &mu;g/ml.&nbsp;&nbsp;Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.</span></span></span>
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Catalog Number R061212
CAS Number 6730-83-2
Molecular Formula

C20H30O2

Purity 95%
Storage -20°C
IUPAC Name (1S,4S,5R,9S,10R,13R)-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid
InChI InChI=1S/C20H30O2/c1-13-11-20-10-7-15-18(2,16(20)6-5-14(13)12-20)8-4-9-19(15,3)17(21)22/h14-16H,1,4-12H2,2-3H3,(H,21,22)/t14-,15+,16+,18-,19-,20-/m1/s1
InChIKey NIKHGUQULKYIGE-OTCXFQBHSA-N
SMILES CC12CCCC(C1CCC34C2CCC(C3)C(=C)C4)(C)C(=O)O
Reference

<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">1.Paiva, L. A. F., et al. &quot;Anti-inflammatory effect of kaurenoic acid, a diterpene from Copaifera langsdorffii on acetic acid-induced colitis in rats.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Vascular pharmacology</i>&nbsp;39.6 (2002): 303-307.<br />
2.Soares, Ana Carolina Ferreira, et al. &quot;Variability of the antibacterial potential among analogue diterpenes against Gram-positive bacteria: considerations on the structure&ndash;activity relationship.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Canadian Journal of Chemistry</i>&nbsp;97.7 (2019): 568-575.</span></span></span>

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