Karanjin

• CAT Number: M004968
• CAS Number: 521-88-0
• Molecular Formula: C18H12O4
• Molecular Weight: 292.29
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 3-methoxy-2-phenylfuro[2,3-h]chromen-4-one
• InChI: InChI=1S/C18H12O4/c1-20-18-15(19)13-7-8-14-12(9-10-21-14)17(13)22-16(18)11-5-3-2-4-6-11/h2-10H,1H3
• InChIKey: LKPQNZRGGNOPPU-UHFFFAOYSA-N
• SMILES: COC1=C(OC2=C(C1=O)C=CC3=C2C=CO3)C4=CC=CC=C4

Karanjin(CAT: M004968) is a natural compound found in the seeds of the tree Pongamia pinnata (also known as Karanj or Indian Beech). Its mode of action involves being a furanoflavonoid with various biological activities. Karanjin has been studied for its potential pharmacological properties, including insecticidal, antimicrobial, and antiviral effects. It has also shown promise in promoting wound healing and possessing anti-inflammatory properties. Due to its interesting bioactivity, Karanjin is of interest in traditional medicine and herbal remedies.

Reference

1: Michaelis M, Rothweiler F, Nerreter T, Sharifi M, Ghafourian T, Cinatl J.
Karanjin interferes with ABCB1, ABCC1, and ABCG2. J Pharm Pharm Sci.
2014;17(1):92-105. PubMed PMID: 24735762.

2: Mandal B, Maity CR. Hypoglycemic action of karanjin. Acta Physiol Pharmacol
Bulg. 1986;12(4):42-6. PubMed PMID: 3577798.

3: Jaiswal N, Yadav PP, Maurya R, Srivastava AK, Tamrakar AK. Karanjin from
Pongamia pinnata induces GLUT4 translocation in skeletal muscle cells in a
phosphatidylinositol-3-kinase-independent manner. Eur J Pharmacol. 2011 Nov
16;670(1):22-8. doi: 10.1016/j.ejphar.2011.08.049. Epub 2011 Sep 14. PubMed PMID:
21939653.

4: Bose M, Chakraborty M, Bhattacharya S, Mukherjee D, Mandal S, Mishra R.
Prevention of arthritis markers in experimental animal and inflammation
signalling in macrophage by Karanjin isolated from Pongamia pinnata seed extract.
Phytother Res. 2014 Aug;28(8):1188-95. doi: 10.1002/ptr.5113. Epub 2014 Jan 7.
PubMed PMID: 24399783.

5: Vismaya, Belagihally SM, Rajashekhar S, Jayaram VB, Dharmesh SM, Thirumakudalu
SK. Gastroprotective Properties of Karanjin from Karanja (Pongamia pinnata)
Seeds; Role as Antioxidant and H, K-ATPase Inhibitor. Evid Based Complement
Alternat Med. 2011;2011:747246. doi: 10.1093/ecam/neq027. Epub 2011 Mar 13.
PubMed PMID: 21799691; PubMed Central PMCID: PMC3137509.

6: Guo JR, Chen QQ, Lam CW, Zhang W. Effects of karanjin on cell cycle arrest and
apoptosis in human A549, HepG2 and HL-60 cancer cells. Biol Res. 2015 Jul
26;48:40. doi: 10.1186/s40659-015-0031-x. PubMed PMID: 26209237; PubMed Central
PMCID: PMC4515023.

7: Katekhaye S, Kale MS, Laddha KS. Development and Validation of an HPLC Method
for Karanjin in Pongamia pinnata linn. Leaves. Indian J Pharm Sci. 2012
Jan;74(1):72-5. doi: 10.4103/0250-474X.102547. PubMed PMID: 23204626; PubMed
Central PMCID: PMC3507349.