K858

• CAT Number: I004714
• CAS Number: 72926-24-0
• Molecular Formula: C₁₃H₁₅N₃O₂S
• Molecular Weight: 277.34
• Purity: ≥95%
• Target: ATPase
• Solubility: 10 mM in DMSO
• Storage: Store at +4C
• IC50: 1.3 μM [1]
• InChI: InChI=1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
• InChIKey: JEFVYQYZCAVNTP-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=NN(C(S1)(C)C2=CC=CC=C2)C(=O)C

K858 (Cat.No:I004714) is a chemical compound with potential pharmaceutical applications. It has been investigated for its inhibitory effects on certain enzymes, receptors, or cellular processes. Further studies are necessary to explore its mechanism of action and assess its potential therapeutic benefits in various fields, such as medicine and biotechnology.

Reference

1:The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells. De Iuliis F, Taglieri L, Salerno G, Giuffrida A, Milana B, Giantulli S, Carradori S, Silvestri I, Scarpa S.Invest New Drugs. 2016 Aug;34(4):399-406. doi: 10.1007/s10637-016-0345-8. Epub 2016 Mar 19. PMID: 26994617 2:K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Nakai R, Iida S, Takahashi T, Tsujita T, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H, Akinaga S, Murakata C, Honda S, Nitta M, Saya H, Yamashita Y.Cancer Res. 2009 May 1;69(9):3901-9. doi: 10.1158/0008-5472.CAN-08-4373. Epub 2009 Apr 7. PMID: 19351824 Free Article