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K-Ras G12C-IN-3

K-Ras G12C-IN-3

  • CAT Number: I002114
  • CAS Number: 1629268-19-4
  • Molecular Formula: C21H19Cl3N2O3
  • Molecular Weight: 453.744
  • Purity: ≥95%
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<p style=/line-height:25px/>K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.<br>IC50 value:<br>Target: K-ras G12C inhibitor<br>For more information, please see the following patent.<br>Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers, and preparation thereof<br>By Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao<br>From PCT Int. Appl. (2014), WO 2014152588 A1 20140925.</p>

Catalog Number I002114
CAS Number 1629268-19-4
Molecular Formula

C21H19Cl3N2O3

Purity 95%
Target Ras
Solubility DMSO: ≥ 40 mg/mL
Storage Store at -20°C
IUPAC Name 1-[4-[4-chloro-5-(2,5-dichlorophenyl)-2-methoxybenzoyl]piperazin-1-yl]prop-2-en-1-one
InChI InChI=1S/C21H19Cl3N2O3/c1-3-20(27)25-6-8-26(9-7-25)21(28)16-11-15(18(24)12-19(16)29-2)14-10-13(22)4-5-17(14)23/h3-5,10-12H,1,6-9H2,2H3
InChIKey RPBHAPLCWWQJAK-UHFFFAOYSA-N
SMILES COC1=C(C=C(C(=C1)Cl)C2=C(C=CC(=C2)Cl)Cl)C(=O)N3CCN(CC3)C(=O)C=C
Reference

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