JWH-133

• CAT Number: I002882
• CAS Number: 259869-55-1
• Molecular Formula: C22H32O
• Molecular Weight: 312.51
• Purity: ≥95%
• Synonyms: 3-(1,1-dimethylbutyl)-6aR,7,10,10aR-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
• Target: target: CB2
• Solubility: 50 mM in DMSO
• Storage: -20°C
• IUPAC Name: (6aR,10aR)-6,6,9-trimethyl-3-(2-methylpentan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene
• InChI: InChI=1S/C22H32O/c1-7-12-21(3,4)16-9-10-17-18-13-15(2)8-11-19(18)22(5,6)23-20(17)14-16/h8-10,14,18-19H,7,11-13H2,1-6H3/t18-,19+/m0/s1
• InChIKey: YSBFLLZNALVODA-RBUKOAKNSA-N
• SMILES: CCCC(C)(C)C(C=C1)=CC2=C1[C@H]3[C@H](C(C)(C)O2)CC=C(C)C3

JWH 133(CAT: I002882) is a potent and selective cannabinoid receptor 2 (CB2) agonist with a Ki of 3.4 nM, demonstrating approximately 200-fold selectivity over CB1 receptors. By targeting CB2 receptors, primarily expressed in immune cells, JWH 133 plays a crucial role in modulating immune responses, inflammation, and pain without the psychoactive effects typically associated with CB1 activation. This makes it particularly relevant in immunology and neuroinflammation research, supporting studies on therapeutic strategies for conditions such as autoimmune diseases, chronic pain, and neurodegenerative disorders. Its high selectivity and efficacy make JWH 133 a valuable tool in advancing cannabinoid-related pharmacology.