JW74- CAS 863405-60-1

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.
IC50 value: 790 nM
Target: Wnt
JW74 increases concentration of AXIN2 and decrease the active form of β-catenin in SW480 colorectal cancer cells. [2] The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines.[1]

Catalog Number: I005177

CAS Number: 863405-60-1

PubChem Substance ID:355048997

Molecular Formula: C24H20N6O2S

Molecular Weight:456.5

Purity: ≥95%

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Molecular Formula: C24H20N6O2S
Molecular Weight456.5
Solubility10 mM in DMSO
StorageStore at -20°C
IC50790 nM

Computed Descriptor