JTE-907

• CAT Number: I007464
• CAS Number: 282089-49-0
• Molecular Formula: C24H26N2O6
• Molecular Weight: 438.48
• Purity: ≥95%
• Target: Cannabinoid Receptor
• Solubility: Soluble in DMSO
• Storage: Store at RT
• IUPAC Name: N-(1,3-benzodioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentoxy-1H-quinoline-3-carboxamide
• InChI: InChI=1S/C24H26N2O6/c1-3-4-5-10-30-22-19(29-2)9-7-16-12-17(24(28)26-21(16)22)23(27)25-13-15-6-8-18-20(11-15)32-14-31-18/h6-9,11-12H,3-5,10,13-14H2,1-2H3,(H,25,27)(H,26,28)
• InChIKey: GRAJFFFXJYFVOC-UHFFFAOYSA-N
• SMILES: CCCCCOC1=C(C=CC2=C1NC(=O)C(=C2)C(=O)NCC3=CC4=C(C=C3)OCO4)OC

JTE-907 (Cat.No:I007464) is a drug used in scientific research that acts as a selective CB2 inverse agonist. It has antiinflammatory effects in animal studies,thought to be mediated by an interaction between the CB2 receptor and IgE.

Reference

1:Upregulation of the expression of inflammatory and angiogenic markers in human adipocytes by a synthetic cannabinoid, JTE-907. González-Muniesa P, Bing C, Trayhurn P.Horm Metab Res. 2010 Sep;42(10):710-7. doi: 10.1055/s-0030-1255119. Epub 2010 Jul 5. PMID: 20603779 2:The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Maekawa T, Nojima H, Kuraishi Y, Aisaka K.Eur J Pharmacol. 2006 Aug 7;542(1-3):179-83. Epub 2006 Jun 2. PMID: 16824511 3:Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice. Ueda Y, Miyagawa N, Matsui T, Kaya T, Iwamura H.Eur J Pharmacol. 2005 Sep 27;520(1-3):164-71. PMID: 16153638 4:In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. Iwamura H, Suzuki H, Ueda Y, Kaya T, Inaba T.J Pharmacol Exp Ther. 2001 Feb;296(2):420-5. PMID: 11160626 Free Article