JTE-013

• CAT Number: I007462
• CAS Number: 383150-41-2
• Molecular Formula: C17H19Cl2N7O
• Molecular Weight: 408.29
• Purity: ≥95%
• Target: S1P2 antagonist
• Solubility: Soluble in DMSO, not in water
• Storage: 2-8°C
• IUPAC Name: 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea
• InChI: InChI=1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27)
• InChIKey: RNSLRQNDXRSASX-UHFFFAOYSA-N
• SMILES: CC1=NN(C2=C1C(=CC(=N2)NNC(=O)NC3=CC(=NC(=C3)Cl)Cl)C(C)C)C

JTE-013（Cat No.:I007462） is a highly potent and selective antagonist of the sphingosine-1-phosphate 2 (S1P2) receptor. It exhibits strong binding affinity to both human and rat S1P2 receptors, with IC50 values of 17 nM and 22 nM, respectively. JTE-013 demonstrates specificity for S1P2, as its IC50 values for human S1P1 and S1P3 receptors are greater than 10 µM, indicating minimal binding affinity. This selectivity profile makes JTE-013 a valuable tool for studying the functions of the S1P2 receptor and exploring its potential as a therapeutic target in various physiological and pathological processes.

Reference

1:Tumor Necrosis Factor-induced Decrease of Cochlear Blood Flow Can Be Reversed by Etanercept or JTE-013. Sharaf K, Ihler F, Bertlich M, Reichel CA, Berghaus A, Canis M.Otol Neurotol. 2016 Aug;37(7):e203-8. doi: 10.1097/MAO.0000000000001095. PMID: 27295443 2:Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor. Li C, Chi XX, Xie W, Strong JA, Zhang JM, Nicol GD.J Neurophysiol. 2012 Sep;108(5):1473-83. doi: 10.1152/jn.00825.2011. Epub 2012 Jun 6. PMID: 22673325 Free PMC Article