JNJ4796

• CAT Number: I019305
• CAS Number: 2241664-16-2
• Molecular Formula: C₂₈H₂₇N₉O₃
• Molecular Weight: 537.57
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-[2-[2-[4-[(R)-(2-methyltetrazol-5-yl)-phenylmethyl]piperazine-1-carbonyl]pyridin-4-yl]-1,3-benzoxazol-5-yl]acetamide
• InChI: InChI=1S/C28H27N9O3/c1-18(38)30-21-8-9-24-22(17-21)31-27(40-24)20-10-11-29-23(16-20)28(39)37-14-12-36(13-15-37)25(19-6-4-3-5-7-19)26-32-34-35(2)33-26/h3-11,16-17,25H,12-15H2,1-2H3,(H,30,38)/t25-/m1/s1
• InChIKey: VMAAUIZLAZYALS-RUZDIDTESA-N
• SMILES: CC(=O)NC1=CC2=C(C=C1)OC(=N2)C3=CC(=NC=C3)C(=O)N4CCN(CC4)C(C5=CC=CC=C5)C6=NN(N=N6)C

JNJ4796（Cat No.:I019305） is an oral active fusion inhibitor of the influenza virus. It acts by neutralizing influenza A group 1 virus through the inhibition of hemagglutinin (HA)-mediated fusion. Mimicking the functionality of broadly neutralizing antibodies (bnAbs), JNJ4796 targets the fusion process, preventing the virus from entering host cells and spreading infection. This mechanism makes JNJ4796 a promising candidate in the fight against influenza, potentially offering an effective therapeutic option.

Reference

[1]. van Dongen MJP, et al. A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science. 2019 Mar 8;363(6431).