JNJ-678

• CAT Number: I020081
• CAS Number: 1383450-81-4
• Molecular Formula: C₂₁H₂₀ClF₃N₄O₃S
• Molecular Weight: 500.92
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 3-[[5-chloro-1-(3-methylsulfonylpropyl)indol-2-yl]methyl]-1-(2,2,2-trifluoroethyl)imidazo[4,5-c]pyridin-2-one
• InChI: InChI=1S/C21H20ClF3N4O3S/c1-33(31,32)8-2-7-27-16(10-14-9-15(22)3-4-17(14)27)12-28-19-11-26-6-5-18(19)29(20(28)30)13-21(23,24)25/h3-6,9-11H,2,7-8,12-13H2,1H3
• InChIKey: GTQTUABHRCWVLL-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)CCCN1C2=C(C=C(C=C2)Cl)C=C1CN3C4=C(C=CN=C4)N(C3=O)CC(F)(F)F

JNJ-678 (Cat No.:I020081) is a respiratory syncytial virus (RSV) fusion inhibitor in clinical development for RSV infection treatment in infants. It selectively binds to the RSV F protein in its prefusion conformation and exhibits potent antiviral activity with low cytotoxicity. JNJ-678 (JNJ-53718678) shows activity against RSV strains of both A and B subtypes, including RSV A2 strain, and has an EC50 of 460 PM in an RSV infection assay using HeLa cells.

Reference

[1]. Roymans D, et al. Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor. Nat Commun. 2017 Aug 1;8(1):167.