JNJ-5207852 dihydrochloride

• CAT Number: I015007
• CAS Number: 1782228-76-5
• Molecular Formula: C₂₀H₃₄Cl₂N₂O
• Molecular Weight: 389.4
• Purity: ≥95%
• IUPAC Name: 1-[3-[4-(piperidin-1-ylmethyl)phenoxy]propyl]piperidine;dihydrochloride
• InChI: InChI=1S/C20H32N2O.2ClH/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22;;/h8-11H,1-7,12-18H2;2*1H
• InChIKey: RLLXSVVZCGBIJR-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)CCCOC2=CC=C(C=C2)CN3CCCCC3.Cl.Cl

JNJ-5207852 dihydrochloride（Cat No.:I015007） is a highly selective and potent antagonist of the histamine H3 receptor (H3R). It exhibits strong binding affinity with pKis values of 8.9 for rat H3R and 9.24 for human H3R. By blocking the H3 receptor, JNJ-5207852 dihydrochloride modulates histamine signaling, which plays a role in various physiological processes, including neurotransmission and inflammation. This compound has been studied for its potential therapeutic applications in conditions such as cognitive disorders and sleep disorders.

Reference

[1]. Barbier AJ, et al. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.[2]. Abuhamdah RM, et al. Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze. Front Syst Neurosci. 2012 Jul 16;6:54.