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J-147

J-147

  • CAT Number: I000545
  • CAS Number: 1146963-51-0
  • Molecular Formula: C18H17F3N2O2
  • Molecular Weight: 350.33
  • Purity: ≥95%
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J-147 (CAT: I000545) is a versatile neuroprotective compound that exhibits potent neurotrophic effects by stimulating the expression of brain-derived neurotrophic factor (BDNF). With an impressive EC50 range of 60-115 nM, J-147 offers broad-spectrum protection against neuronal degeneration. Its unique phenyl hydrazide structure contributes to its ability to enhance cellular resilience and promote neuron health.

Catalog Number I000545
CAS Number 1146963-51-0
Molecular Formula

C18H17F3N2O2

Purity 95%
Target Amyloid β
Solubility 10 mM in DMSO
Storage Store at +4C
IC50 60-115 nM in vitro assay [1]
InChI InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+
InChIKey HYMZAYGFKNNHDN-SSDVNMTOSA-N
SMILES O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC)=C2)C(F)(F)F
Reference

</br>1:SU-E-J-147: Dosimetric Consequences of Intrafraction Prostate Motion: Comparison Between Phantom Measurements and Three Different Calculation Methods. Schmitt D, Nill S, Roeder F, Herfarth K, Oelfke U.Med Phys. 2012 Jun;39(6Part8):3686. doi: 10.1118/1.4734984. PMID: 28518909 </br>2:J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeTox<sup>™</sup> Safety and Genotoxicity Analysis. Lapchak PA, Bombien R, Rajput PS.J Neurol Neurophysiol. 2013 Aug;4(3). pii: 158. PMID: 25364619 Free PMC Article

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