IWP-2

• CAT Number: I004582
• CAS Number: 686770-61-6
• Molecular Formula: C₂₂H₁₈N₄O₃S₃
• Molecular Weight: 466.6
• Purity: ≥95%
• Target: Wnt/β-catenin
• Solubility: DMSO: ＜ 4.7 mg/mL
• Storage: 3 years -20C powder
• IC50: 27 nM
• InChI: InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
• InChIKey: WRKPZSMRWPJJDH-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4

IWP-2 (CAT: I004582) is a small molecule inhibitor that specifically targets the Wnt signaling pathway. It functions by inhibiting the enzyme Porcupine, which is responsible for the lipid modification of Wnt proteins. By blocking Wnt secretion and preventing its binding to cell surface receptors, IWP-2 effectively disrupts Wnt signaling. This pathway plays a crucial role in embryonic development, tissue homeostasis, and stem cell maintenance. IWP-2 has been widely used in research to study the role of Wnt signaling in various biological processes, including embryogenesis, tissue regeneration, and cancer. Its selective inhibition of Porcupine makes it a valuable tool for investigating Wnt-related diseases and potential therapeutic targets.

Reference

[1]. Chen B, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7.
[2]. Frewer KA, et al. A role for WISP2 in colorectal cancer cell invasion and motility. Cancer Genomics Proteomics. 2013 Jul-Aug;10(4):187-96.
[3]. Mo ML, et al. Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer. Oncol Lett. 2013 May;5(5):1719-1723.
[4]. Mureli S, et al. Mesenchymal stem cells improve cardiac conduction by upregulation of connexin 43 through paracrine signaling. Am J Physiol Heart Circ Physiol. 2013 Feb 15;304(4):H600-9.