For research use only. Not for therapeutic Use.
IWP-12（Cat No.:I011156）is a potent and selective inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase essential for the palmitoylation and secretion of Wnt proteins. By blocking PORCN activity, IWP-12 effectively suppresses Wnt/β-catenin signaling, a pathway critical for embryonic development, tissue regeneration, and cancer progression. It is widely used in developmental biology and oncology research to investigate Wnt-dependent processes and to explore therapeutic strategies targeting aberrant Wnt signaling. IWP-12 serves as a valuable tool for studying Wnt pathway regulation, stem cell biology, and the molecular mechanisms of Wnt-driven diseases.
| CAS Number | 688353-45-9 |
| Synonyms | 2-[(3,6-dimethyl-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide |
| Molecular Formula | C18H18N4O2S3 |
| Purity | ≥95% |
| IUPAC Name | 2-[(3,6-dimethyl-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide |
| InChI | InChI=1S/C18H18N4O2S3/c1-9-4-5-11-13(6-9)27-17(19-11)21-14(23)8-25-18-20-12-7-10(2)26-15(12)16(24)22(18)3/h4-6,10H,7-8H2,1-3H3,(H,19,21,23) |
| InChIKey | RBFDSBJDWZOTGR-UHFFFAOYSA-N |
| SMILES | CC1CC2=C(S1)C(=O)N(C(=N2)SCC(=O)NC3=NC4=C(S3)C=C(C=C4)C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
